Revolutionary therapeutics inspired by naturally occurring biomolecules
Proprietary cyclic peptides bio-inspired by natural anti-inflammatory and anti-microbial effectors of host defense, theta defensins.
Unique Properties of Orynotides
Orynotides are engineered analogs of theta-defensins, macrocyclic peptide molecules that occur naturally in some species of primates, but not humans. Like naturally occurring theta defensins, Oryntides are stable with low toxicity and low immunogenicity.
Humans and monkeys all have the genes and produce the mRNA, but stop codons block biosynthesis of the peptide in humans. This discovery of theta-defensins altered and expanded the scientific view of animal innate immunity.
It was previously believed cyclic peptides were only produced in a few plants and by some bacteria. Their discovery in nonhuman primates disclosed the presence of a new host defense system.
Engineering Novel Therapeutics
Oryn Therapeutics pioneered research into the therapeutic properties of theta defensins. Company scientists have employed a novel retro-evolutionary approach that has given rise to novel immunoregulatory therapeutics effective in preclinical models of infectious, inflammatory, autoimmune diseases as well as cancer.
Theta Defensins:
The Bioinspired Template for Orynotides
Rhesus theta defensin 1 (RTD-1) molecular ribbon diagram showing backbone (blue) cyclized peptide stabilized by 3 disulfide bonds (yellow).
ORYN 1001 is just the beginning.
