Unique Properties of Orynotides
Orynotides are engineered analogs of theta-defensins, macrocyclic peptide molecules that occur naturally in some species of primates, but not humans. Like naturally occurring theta defensins, Oryntides are stable with low toxicity and low immunogenicity.
Humans and monkeys all have the genes and produce the mRNA, but stop codons block biosynthesis of the peptide in humans. This discovery of theta-defensins altered and expanded the scientific view of animal innate immunity.
It was previously believed cyclic peptides were only produced in a few plants and by some bacteria. Their discovery in nonhuman primates disclosed the presence of a new host defense system.